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Science 29 June 2001:
Vol. 292. no. 5526, pp. 2415 - 2417
DOI: 10.1126/science.292.5526.2415
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News of the Week

CELL CYCLE RESEARCH:
DNA: Once Copied, Thrice Blocked

R. John Davenport

Although more than a decade ago cell biologists identified the master protein that guarantees that DNA replication occurs only once, they don't understand how it exerts its power. Now, part of that puzzle has been solved. In the 28 June issue of Nature, a team reports that three separate pathways, all under the control of the master coordinator, a protein kinase known as Clb-Cdc28, must work together to prevent a second round of DNA synthesis from getting under way before the cell divides.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Loss of Meiotic Rereplication Block in Saccharomyces cerevisiae Cells Defective in Cdc28p Regulation.
L. M. Rice, C. Plakas, and J. T. Nickels Jr. (2005)
Eukaryot. Cell 4, 55-62
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