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Science 8 June 2001:
Vol. 292. no. 5523, pp. 1851 - 1852
DOI: 10.1126/science.1062238
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Perspectives

MOLECULAR BIOLOGY:
Getting p53 Out of the Nucleus

Vanesa Gottifredi and Carol Prives

Why does the p53 tumor suppressor protein need two nuclear export signals? In their Perspective, Gottifredi and Prives set out to answer this question. They discuss new findings (Zhang and Xiong) suggesting that, in the unstressed cell, the two nuclear export signals may act together to promote the movement of p53 from the nucleus into the cytoplasm, where it is degraded.

The authors are in the Department of Biological Sciences, Columbia University, New York, NY 10027, USA. E-mail: clp3{at}columbia.edu

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