Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Originally published in Science Express on 10 May 2001
Science 1 June 2001:
Vol. 292. no. 5522, pp. 1667 - 1668
DOI: 10.1126/science.1061542
Prev | Table of Contents | Next

Perspectives

IMMUNOLOGY:
Agrin--A Bridge Between the Nervous and Immune Systems

Alain Trautmann and Eric Vivier

Agrin--a glycoprotein known to be important in the formation of neuronal synapses, particularly those between motor neurons and muscle cells (neuromuscular junctions)--now has been found on the surface of T lymphocytes (Khan et al.). In an informative odyssey through the land of neuronal and immunological synapses, Trautmann and Vivier reveal the similarities and differences between neuronal and immune cell agrin and reveal what this molecule does in neuromuscular junctions and in synapses between T cells and antigen-presenting cells.

A. Trautmann is in the Laboratoire d'Immuno-Pharmacologie, CNRS UPR 415, ICGM, Paris, France; e-mail: trautmann{at}cochin.inserm.fr. E. Vivier is at the Institut Universitaire de France and Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université Medicale, Campus de Luminy, Marseille, France; e-mail: vivier{at}ciml.univ-mrs.fr.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.
J. L. Round, T. Tomassian, M. Zhang, V. Patel, S. P. Schoenberger, and M. C. Miceli (2005)
J. Exp. Med. 201, 419-430
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)