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Science 11 May 2001:
Vol. 292. no. 5519, pp. 1075 - 1076
DOI: 10.1126/science.1061032
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

CELL BIOLOGY:
Enhanced: Telomere Capping--One Strand Fits All

Titia de Lange

How do different organisms protect the ends of their chromosomes (telomeres) from being degraded? Although at first sight it seems that organisms as diverse as ciliates, yeast, and mammalian cells have chosen different modes of telomere protection, it now transpires, as De Lange explains in her Perspective, that they all have one thing in common: a single-stranded DNA binding protein that forms a protective cap over the end of the telomere (Baumann and Cech).

The author is at the Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA. E-mail: delange{at}mail.rockefeller.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Shelterin: the protein complex that shapes and safeguards human telomeres.
T. de Lange (2005)
Genes & Dev. 19, 2100-2110
   Abstract »    Full Text »    PDF »
POT1 and TRF2 Cooperate To Maintain Telomeric Integrity.
Q. Yang, Y.-L. Zheng, and C. C. Harris (2005)
Mol. Cell. Biol. 25, 1070-1080
   Abstract »    Full Text »    PDF »
Processive Utilization of the Human Telomerase Template: LACK OF A REQUIREMENT FOR TEMPLATE SWITCHING.
M. A. Rivera and E. H. Blackburn (2004)
J. Biol. Chem. 279, 53770-53781
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Degradation of p53, Not Telomerase Activation, by E6 Is Required for Bypass of Crisis and Immortalization by Human Papillomavirus Type 16 E6/E7.
H. R. McMurray and D. J. McCance (2004)
J. Virol. 78, 5698-5706
   Abstract »    Full Text »    PDF »
Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86.
K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
Mol. Cell. Biol. 24, 5050-5059
   Abstract »    Full Text »    PDF »
Biochemical evidence for Ku-independent backup pathways of NHEJ.
H. Wang, A. R. Perrault, Y. Takeda, W. Qin, H. Wang, and G. Iliakis (2003)
Nucleic Acids Res. 31, 5377-5388
   Abstract »    Full Text »    PDF »
Sequence-specific Binding to Telomeric DNA by CEH-37, a Homeodomain Protein in the Nematode Caenorhabditis elegans.
S. H. Kim, S. B. Hwang, I. K. Chung, and J. Lee (2003)
J. Biol. Chem. 278, 28038-28044
   Abstract »    Full Text »    PDF »
Telomere shortening in leukocyte subpopulations from baboons.
G. M. Baerlocher, J. Mak, A. Roth, K. S. Rice, and P. M. Lansdorp (2003)
J. Leukoc. Biol. 73, 289-296
   Abstract »    Full Text »    PDF »
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1.
K. Itahana, Y. Zou, Y. Itahana, J.-L. Martinez, C. Beausejour, J. J. L. Jacobs, M. van Lohuizen, V. Band, J. Campisi, and G. P. Dimri (2003)
Mol. Cell. Biol. 23, 389-401
   Abstract »    Full Text »
Delineation of the high-affinity single-stranded telomeric DNA-binding domain of Saccharomyces cerevisiae Cdc13.
E. M. Anderson, W. A. Halsey, and D. S. Wuttke (2002)
Nucleic Acids Res. 30, 4305-4313
   Abstract »    Full Text »    PDF »
Secondary structure polymorphism in Oxytricha nova telomeric DNA.
C. Krafft, J. M. Benevides, and G. J. Thomas Jr (2002)
Nucleic Acids Res. 30, 3981-3991
   Abstract »    Full Text »    PDF »
Reversible Manipulation of Telomerase Expression and Telomere Length. IMPLICATIONS FOR THE IONIZING RADIATION RESPONSE AND REPLICATIVE SENESCENCE OF HUMAN CELLS.
M. A. Rubio, S.-H. Kim, and J. Campisi (2002)
J. Biol. Chem. 277, 28609-28617
   Abstract »    Full Text »    PDF »
Conserved Structure for Single-Stranded Telomeric DNA Recognition.
R. M. Mitton-Fry, E. M. Anderson, T. R. Hughes, V. Lundblad, and D. S. Wuttke (2002)
Science 296, 145-147
   Abstract »    Full Text »    PDF »


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