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Science 27 April 2001:
Vol. 292. no. 5517, pp. 647 - 648
DOI: 10.1126/science.1060857
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

MICROBIOLOGY:
Enhanced: Fighting Anthrax with a Mutant Toxin

Sjur Olsnes and Jørgen Wesche

There is an urgent need to develop new therapeutics against the microbe causing anthrax, which has the potential to be used in biological warfare. In their Perspective, Olsnes and Wesche discuss a new therapeutic approach designed by Sellman and colleagues. In this approach, a mutant subunit of the toxin prevents correct assembly of wild-type subunits into a pore in the host cell membrane. In this way, lethal bacterial enzymes are prevented from translocating into the host cell.

The authors are in the Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway. E-mail: olsnes{at}radium.uio.no

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Science. ISSN 0036-8075 (print), 1095-9203 (online)