Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 April 2001:
Vol. 292. no. 5516, pp. 426 - 429
DOI: 10.1126/science.292.5516.426
Prev | Table of Contents | Next

News Focus

CELL BIOLOGY:
Do Centrosome Abnormalities Lead to Cancer?

Jean Marx

Evidence suggests that at least some cancers arise because malfunctions in the centrosome, which plays a key role in cell division, cause chromosome damage and missorting. Contributing to this new view is the realization that many types of cancer cells have abnormalities in their centrosomes. The supposition is that these abnormalities lead to chromosome instability, which may, in turn, result in the loss of tumor suppressor genes or the gain or activation of cancer-causing oncogenes. Researchers caution that this idea isn't yet firmly established, but if centrosome abnormalities underlie some of the chromosomal instability seen in cancer, they might be useful as diagnostic or prognostic indicators to help clinicians distinguish highly malignant cancers from those that are less dangerous.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
BRCA1 Interaction of Centrosomal Protein Nlp Is Required for Successful Mitotic Progression.
S. Jin, H. Gao, L. Mazzacurati, Y. Wang, W. Fan, Q. Chen, W. Yu, M. Wang, X. Zhu, C. Zhang, et al. (2009)
J. Biol. Chem. 284, 22970-22977
   Abstract »    Full Text »    PDF »
Megakaryocytes express functional Aurora-B kinase in endomitosis.
A. E. Geddis and K. Kaushansky (2004)
Blood 104, 1017-1024
   Abstract »    Full Text »    PDF »
The Role of p53 in Suppression of KSHV Cyclin-induced Lymphomagenesis.
E. W. Verschuren, J. G. Hodgson, J. W. Gray, S. Kogan, N. Jones, and G. I. Evan (2004)
Cancer Res. 64, 581-589
   Abstract »    Full Text »    PDF »
The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line.
G. Goshima and R. D. Vale (2003)
J. Cell Biol. 162, 1003-1016
   Abstract »    Full Text »    PDF »
Lsh-deficient Murine Embryonal Fibroblasts Show Reduced Proliferation with Signs of Abnormal Mitosis.
T. Fan, Q. Yan, J. Huang, S. Austin, E. Cho, D. Ferris, and K. Muegge (2003)
Cancer Res. 63, 4677-4683
   Abstract »    Full Text »    PDF »
Centrosomes Split in the Presence of Impaired DNA Integrity during Mitosis.
H. M.J. Hut, W. Lemstra, E. H. Blaauw, G. W.A. van Cappellen, H. H. Kampinga, and O. C.M. Sibon (2003)
Mol. Biol. Cell 14, 1993-2004
   Abstract »    Full Text »    PDF »
Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile.
K. Neben, C. Giesecke, S. Schweizer, A. D. Ho, and A. Kramer (2003)
Blood 101, 289-291
   Abstract »    Full Text »    PDF »
The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.
J. Du and G. J. Hannon (2002)
Nucleic Acids Res. 30, 5465-5475
   Abstract »    Full Text »    PDF »
Centrosome Amplification and Overexpression of Aurora A Are Early Events in Rat Mammary Carcinogenesis.
T. M. Goepfert, Y. E. Adigun, L. Zhong, J. Gay, D. Medina, and W. R. Brinkley (2002)
Cancer Res. 62, 4115-4122
   Abstract »    Full Text »    PDF »
Cross signaling, cell specificity, and physiology.
J. E. Dumont, S. Dremier, I. Pirson, and C. Maenhaut (2002)
Am J Physiol Cell Physiol 283, C2-C28
   Abstract »    Full Text »    PDF »
Cell Cycle Arrest and Apoptosis Induced by Human Polo-Like Kinase 3 Is Mediated through Perturbation of Microtubule Integrity.
Q. Wang, S. Xie, J. Chen, K. Fukasawa, U. Naik, F. Traganos, Z. Darzynkiewicz, M. Jhanwar-Uniyal, and W. Dai (2002)
Mol. Cell. Biol. 22, 3450-3459
   Abstract »    Full Text »    PDF »
Cell-cycle-dependent Regulation of Human aurora A Transcription Is Mediated by Periodic Repression of E4TF1.
M. Tanaka, A. Ueda, H. Kanamori, H. Ideguchi, J. Yang, S. Kitajima, and Y. Ishigatsubo (2002)
J. Biol. Chem. 277, 10719-10726
   Abstract »    Full Text »    PDF »
Calcium, Calmodulin, and CaMKII Requirement for Initiation of Centrosome Duplication in Xenopus Egg Extracts.
Y. Matsumoto and J. L. Maller (2002)
Science 295, 499-502
   Abstract »    Full Text »    PDF »
The Schizosaccharomyces pombe Aurora-related Kinase Ark1 Interacts with the Inner Centromere Protein Pic1 and Mediates Chromosome Segregation and Cytokinesis.
J. D. Leverson, H.-k. Huang, S. L. Forsburg, and T. Hunter (2002)
Mol. Biol. Cell 13, 1132-1143
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)