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Science 6 April 2001:
Vol. 292. no. 5514, pp. 64 - 65
DOI: 10.1126/science.1060028
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Perspectives

MOLECULAR BIOLOGY:
The Histone Modification Circus

Shelley L. Berger

The histone proteins that constitute the nucleosomes of chromatin around which yards of DNA are wrapped undergo a series of chemical modifications during gene activation and gene silencing. In a Perspective, Berger discusses new results (Nakayama et al.) that elucidate the sequence of reactions that modify histone H3 and how these modifications translate into gene silencing in fission yeast.

The author is in the Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA. E-mail: berger{at}wistar.upenn.edu

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