Sugar Separates Humans From Apes

doi:10.1126/science.291.5512.2340a

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Science 23 March 2001:
Vol. 291. no. 5512, p. 2340
DOI: 10.1126/science.291.5512.2340a

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Sugar Separates Humans From Apes

Joseph Alper

So far, the only identified gene that differs between humans and chimpanzees codes for an enzyme that makes a particular form of a sugar called sialic acid: Chimps, and all other mammals for that matter, have the gene, while humans do not. To Ajit and Nissi Varki, this fact may provide a clue to how evolutionary pressure and molecular biology interact to produce changes that have multiple consequences.

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INTRODUCTION TO SPECIAL ISSUE Cinderella's Coach Is Ready: Stella Hurtley, Robert Service, and Phil Szuromi (23 March 2001)
Science 291 (5512), 2337. [DOI: 10.1126/science.291.5512.2337]
| Summary »

NEWS Searching for Medicine's Sweet Spot: Joseph Alper (23 March 2001)
Science 291 (5512), 2338. [DOI: 10.1126/science.291.5512.2338]
| Summary » | Full Text »

NEWS Saving Lives With Sugar: Joseph Alper (23 March 2001)
Science 291 (5512), 2339. [DOI: 10.1126/science.291.5512.2339]
| Summary » | Full Text »

NEWS After the Fall: Robert F. Service (23 March 2001)
Science 291 (5512), 2340b. [DOI: 10.1126/science.291.5512.2340b]
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NEWS The Best of Both Worlds?: Robert F. Service (23 March 2001)
Science 291 (5512), 2342. [DOI: 10.1126/science.291.5512.2342]
| Summary » | Full Text »

NEWS Bent Out of Shape: Michael Balter (23 March 2001)
Science 291 (5512), 2343. [DOI: 10.1126/science.291.5512.2343]
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REVIEW Toward Automated Synthesis of Oligosaccharides and Glycoproteins: Pamela Sears and Chi-Huey Wong (23 March 2001)
Science 291 (5512), 2344. [DOI: 10.1126/science.1058899]
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REVIEW Glycoprotein Structure Determination by Mass Spectrometry: Anne Dell and Howard R. Morris (23 March 2001)
Science 291 (5512), 2351. [DOI: 10.1126/science.1058890]
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REVIEW Chemical Glycobiology: Carolyn R. Bertozzi and Laura L. Kiessling (23 March 2001)
Science 291 (5512), 2357. [DOI: 10.1126/science.1059820]
| Abstract » | Full Text » | PDF »

REVIEW Intracellular Functions of N-Linked Glycans: Ari Helenius and Markus Aebi (23 March 2001)
Science 291 (5512), 2364. [DOI: 10.1126/science.291.5512.2364]
| Abstract » | Full Text » | PDF »

REVIEW Glycosylation and the Immune System: Pauline M. Rudd, Tim Elliott, Peter Cresswell, Ian A. Wilson, and Raymond A. Dwek (23 March 2001)
Science 291 (5512), 2370. [DOI: 10.1126/science.291.5512.2370]
| Abstract » | Full Text » | PDF »

VIEWPOINT Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc: Lance Wells, Keith Vosseller, and Gerald W. Hart (23 March 2001)
Science 291 (5512), 2376. [DOI: 10.1126/science.1058714]
| Abstract » | Full Text » | PDF »

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Sugar Separates Humans From Apes

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