Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 March 2001:
Vol. 291. no. 5512, pp. 2338 - 2343
DOI: 10.1126/science.291.5512.2338
Prev | Table of Contents | Next

News

Searching for Medicine's Sweet Spot

Joseph Alper

Carbohydrates have long been avoided by chemists and biologists because of their structural complexity, which makes them difficult to analyze and extremely difficult to synthesize. Now, recent advances in the study of carbohydrate chemistry and biology have put sugar-based drugs on medicine's menu, where they are garnering impressive early reviews. Carbohydrate compounds are currently in clinical trials aimed at fighting everything from inflammation and tissue rejection to hepatitis and cancer.

As a Web supplement to this special issue on Carbohydrates and Glycobiology, Science Online has gathered a page of particularly interesting Web resources in organic chemistry, carbohydrate chemistry, and glycobiology; see www.sciencemag.org/feature/data/carbohydrates.shl.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system.
A. C. Goodwin, D. M. Weinberger, C. B. Ford, J. C. Nelson, J. D. Snider, J. D. Hall, C. I. Paules, R. M. Peek Jr, and M. H. Forsyth (2008)
Microbiology 154, 2231-2240
   Abstract »    Full Text »    PDF »
A molecular analysis of ascidian metamorphosis reveals activation of an innate immune response.
B. Davidson and B. J. Swalla (2003)
Development 129, 4739-4751
   Abstract »    Full Text »    PDF »
Sweet solution: sugars to the rescue.
H. H. Freeze (2002)
J. Cell Biol. 158, 615-616
   Abstract »    Full Text »    PDF »
Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation.
J. Mahdavi, B. Sonden, M. Hurtig, F. O. Olfat, L. Forsberg, N. Roche, J. Angstrom, T. Larsson, S. Teneberg, K.-A. Karlsson, et al. (2002)
Science 297, 573-578
   Abstract »    Full Text »    PDF »
Antiviral Effects of an Iminosugar Derivative on Flavivirus Infections.
S.-F. Wu, C.-J. Lee, C.-L. Liao, R. A. Dwek, N. Zitzmann, and Y.-L. Lin (2002)
J. Virol. 76, 3596-3604
   Abstract »    Full Text »    PDF »
Update and perspectives on congenital disorders of glycosylation.
H. H. Freeze (2001)
Glycobiology 11, 129R-143R
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)