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Originally published in Science Express on 1 March 2001
Science 23 March 2001:
Vol. 291. no. 5512, pp. 2323 - 2324
DOI: 10.1126/science.1059984
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Perspectives

IMMUNOLOGY:
Memory T Cells--Local Heroes in the Struggle for Immunity

Charles R. Mackay and Ulrich H. von Andrian

Many of the cellular and molecular processes involved in forming and maintaining immunological memory are still unknown. In their Perspective, Mackay and von Andrian discuss new work that tracks the migration of antigen-stimulated memory T cells from the lymphoid tissues to nonlymphoid tissues where they form the first line of defense against pathogens that are reencountered. Memory T cells that remain in the lymphoid tissues constitute the backup team, that comes to the rescue when the nonlymphoid memory T cells become overwhelmed.

C. R. Mackay is with the Arthritis and Asthma program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia. U. H. von Andrian is in the Department of Pathology, Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA. E-mail: c.mackay@garvan.unsw.edu.au; uva{at}cbr.med.harvard.edu

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