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Science 9 March 2001:
Vol. 291. no. 5510, pp. 1915 - 1916
DOI: 10.1126/science.1059671
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Perspectives

MICROBIOLOGY:
Signaling Antibiotic Resistance in Staphylococci

Gordon L. Archer and Joseph M. Bosilevac

For 30 years biologists have studied the molecular machinery of staphylococcal bacteria that renders them resistant to b-lactam antibiotics. In a Perspective, Archer and Bosilevac discuss new findings showing that cleavage of a sensor-transducer protein after it binds to a b-lactam antibiotic results in cleavage of the repressor protein that binds to the blaZ gene. b-Lactamase is then produced and binds to and inactivates the antibiotic.

The authors are in the Departments of Medicine and Microbiology/Immunology, Medical College of Virginia/Commonwealth University, Richmond, VA 23298, USA. E-mail: garcher@hsc.vcu.edu, jnbosile{at}hsc.vcu.edu

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