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Science 9 March 2001:
Vol. 291. no. 5510, pp. 1910 - 1911
DOI: 10.1126/science.1059938
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Perspectives

DEVELOPMENTAL NEUROSCIENCE:
Moving On

Barry J. Dickson

In the developing embryo, commissural axons migrate from one side of the body, across the midline to the other side under the influence of guidance cues. But how is it that axons can be attracted to the midline by netrin, yet are able to ignore netrin's attractive signal once they have crossed the midline? In his Perspective, Dickson takes us on an axonal odyssey describing the adept ability of commissural axons to change their preferences for guidance cues depending on which side of the midline they are on.

The author is at the Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. E-mail: dickson{at}nt.imp.univie.ac.at

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Netrins and neogenin promote myotube formation.
J.-S. Kang, M.-J. Yi, W. Zhang, J. L. Feinleib, F. Cole, and R. S. Krauss (2004)
J. Cell Biol. 167, 493-504
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Science. ISSN 0036-8075 (print), 1095-9203 (online)