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Science 23 February 2001:
Vol. 291. no. 5508, p. 1443
DOI: 10.1126/science.291.5508.1443g
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Nucleic acids and many polypeptides can be readily synthesized by automated solid-phase synthesizers. Carbohydrate synthesis has been more labor intensive, and each step, whether in solution or taking advantage of solid-phase supports, is normally done by hand. Plante et al. (p. 1523; see the news story by Service, 2 Feb.) now report that several carbohydrates can be synthesized in an automated fashion with glycosyl phosphate and trichloroacetimidate building blocks supported on an octenediol-functionalized resin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)