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Science 23 February 2001:
Vol. 291. no. 5508, p. 1443
DOI: 10.1126/science.291.5508.1443e
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B cells appropriate help from T cells by expressing of class II molecules, which display antigenic peptides to specific receptors expressed by the T cells. These receptors are wired up to complex intracellular signaling pathways that launch a program of activation and differentiation in the T cell upon the recognition of appropriate antigen. Lang et al. (p. 1537) provide evidence that the interaction between the T cell receptor and class II molecule is not simply a one-way exchange of information. Signals could be delivered back to the B cell via the class II molecules. This process depended upon their association with the signaling chains of the B cell antigen receptor. This process may play a role in regulating T cell-B cell cooperation during immune responses to antigen.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)