Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 February 2001:
Vol. 291. no. 5507, pp. 1255 - 1257
DOI: 10.1126/science.1058969
Prev | Table of Contents | Next

Viewpoint

GENE NUMBER:
What If There Are Only 30,000 Human Genes?

Jean-Michel Claverie

The complete assembly of the entire human genome sequence by Venter et al. confirms recent estimates that the total number of human protein coding genes might be less than 30,000--a mere one-third increase over the nematode Caenorhabditis elegans. Such a low gene number constitutes a paradigm change, which could drastically modify our understanding of organism complexity and evolution, as well as our current interpretation of transcriptome analyses. It may also have severe consequences on the long-term sustainability of the biomedical industry in the postgenomic era.

Structural & Genetic Information Laboratory, CNRS-AVENTIS UMR 1889 31 Chemin Joseph Aiguier, 13402, Marseille, France. E-mail: Jean-Michel.Claverie{at}igs.cnrs-mrs.fr

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
KBERG: KnowledgeBase for Estrogen Responsive Genes.
S. Tang, Z. Zhang, S. L. Tan, M.-H. E. Tang, A. P. Kumar, S. K. Ramadoss, and V. B. Bajic (2007)
Nucleic Acids Res. 35, D732-D736
   Abstract »    Full Text »    PDF »
'Genome design' model and multicellular complexity: golden middle.
A. E. Vinogradov (2006)
Nucleic Acids Res. 34, 5906-5914
   Abstract »    Full Text »    PDF »
N-ethyl-N-nitrosourea (ENU) mutagenesis and male fertility research.
C.L. Kennedy and M.K. O'Bryan (2006)
Hum. Reprod. Update 12, 293-301
   Abstract »    Full Text »    PDF »
An artificial riboswitch for controlling pre-mRNA splicing.
D.-S. KIM, V. GUSTI, S. G. PILLAI, and R. K. GAUR (2005)
RNA 11, 1667-1677
   Abstract »    Full Text »    PDF »
Fewer Genes, More Noncoding RNA.
J.-M. Claverie (2005)
Science 309, 1529-1530
   Abstract »    Full Text »    PDF »
Large-scale cDNA transfection screening for genes related to cancer development and progression.
D. Wan, Y. Gong, W. Qin, P. Zhang, J. Li, L. Wei, X. Zhou, H. Li, X. Qiu, F. Zhong, et al. (2004)
PNAS 101, 15724-15729
   Abstract »    Full Text »    PDF »
An ORFeome-based Analysis of Human Transcription Factor Genes and the Construction of a Microarray to Interrogate Their Expression.
D. N. Messina, J. Glasscock, W. Gish, and M. Lovett (2004)
Genome Res. 14, 2041-2047
   Abstract »    Full Text »    PDF »
The interactome as a tree--an attempt to visualize the protein-protein interaction network in yeast.
H. Lu, X. Zhu, H. Liu, G. Skogerbo, J. Zhang, Y. Zhang, L. Cai, Y. Zhao, S. Sun, J. Xu, et al. (2004)
Nucleic Acids Res. 32, 4804-4811
   Abstract »    Full Text »    PDF »
Computational comparative analyses of alternative splicing regulation using full-length cDNA of various eukaryotes.
H. ITOH, T. WASHIO, and M. TOMITA (2004)
RNA 10, 1005-1018
   Abstract »    Full Text »    PDF »
Reconciling the Numbers: ESTs Versus Protein-Coding Genes.
A. Nekrutenko (2004)
Mol. Biol. Evol. 21, 1278-1282
   Abstract »    Full Text »    PDF »
Computational physiology and the physiome project.
E. J. Crampin, M. Halstead, P. Hunter, P. Nielsen, D. Noble, N. Smith, and M. Tawhai (2004)
Exp Physiol 89, 1-26
   Abstract »    Full Text »    PDF »
Renovating the House of Being: Genomes, Souls, and Selves.
A. MAURON (2003)
Ann. N.Y. Acad. Sci. 1001, 240-252
   Abstract »    Full Text »    PDF »
Differential Amplification of Gene Expression in Lens Cell Lines Conditioned to Survive Peroxide Stress.
A. Spector, D. Li, W. Ma, F. Sun, and P. Pavlidis (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3251-3264
   Abstract »    Full Text »    PDF »
Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening.
D. D. Carson, E. Lagow, A. Thathiah, R. Al-Shami, M. C. Farach-Carson, M. Vernon, L. Yuan, M. A. Fritz, and B. Lessey (2002)
Mol. Hum. Reprod. 8, 871-879
   Abstract »    Full Text »    PDF »
Survey of Transcript Expression in Rainbow Trout Leukocytes Reveals a Major Contribution of Interferon-Responsive Genes in the Early Response to a Rhabdovirus Infection.
C. O'Farrell, N. Vaghefi, M. Cantonnet, B. Buteau, P. Boudinot, and A. Benmansour (2002)
J. Virol. 76, 8040-8049
   Abstract »    Full Text »    PDF »
A question of size: the eukaryotic proteome and the problems in defining it.
P. M. Harrison, A. Kumar, N. Lang, M. Snyder, and M. Gerstein (2002)
Nucleic Acids Res. 30, 1083-1090
   Abstract »    Full Text »    PDF »
The glycosynapse.
S.-i. Hakomori (2002)
PNAS
   Abstract »    Full Text »    PDF »
Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.
R. Zwart, F. Sleutels, A. Wutz, A. H. Schinkel, and D. P. Barlow (2001)
Genes & Dev. 15, 2361-2366
   Abstract »    Full Text »    PDF »
Mapping of Quantitative Trait Loci with Knockout/Congenic Strains.
V. J. Bolivar, M. N. Cook, and L. Flaherty (2001)
Genome Res. 11, 1549-1552
   Abstract »    Full Text »    PDF »
Inaugural Article: The glycosynapse.
S.-i. Hakomori (2002)
PNAS 99, 225-232
   Abstract »    Full Text »    PDF »
Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway Analysis.
N. D. Price, J. A. Papin, and B. O. Palsson (2002)
Genome Res. 12, 760-769
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products