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Science 16 February 2001:
Vol. 291. no. 5507, pp. 1224 - 1229
DOI: 10.1126/science.291.5507.1224
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GENOMICS AND MEDICINE:
Dissecting Human Disease in the Postgenomic Era

Leena Peltonen and Victor A. McKusick

The genomics era has provided great opportunities for deciphering the genes that are mutated in human diseases. In their Future Directions' article, Peltonen and McKusick discuss how the human genome sequence and the completed genome sequences of other organisms will expand our understanding of human diseases, both those caused by mutations in a single gene and those where many genes and multiple factors are involved. From SNP maps to individual drug response profiling, the human genome sequence will lead to improved diagnostic testing for disease susceptibility genes and individually tailored treatment regimens for those who have already developed disease symptoms.

L. Peltonen is in the Department of Human Genetics, University of California Los Angeles School of Medicine, Los Angeles, CA 90095-7088, USA. E-mail: lpeltonen{at}mednet.ucla.edu V. A. McKusick is in the Department of Medical Genetics, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

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