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CELL BIOLOGY: A Lipid Oils the Endocytosis Machine
David J. Gillooly and Harald Stenmark
Endocytosis, the formation of membrane vesicles that carry various cargo, is a crucial feature of a cell's transportation system. In a Perspective, Gillooly and Stenmark discuss new findings (Ford et al., and Itoh et al.) showing that the membrane lipid PIP2 (phosphatidylinositol-4,5-bisphosphate) is crucial for assembling the molecular machinery of endocytosis.
The authors are in the Department of Biochemistry, Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway. E-mail: stenmark{at}ulrik.uio.no
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Toshiki Itoh, Seizo Koshiba, Takanori Kigawa, Akira Kikuchi, Shigeyuki Yokoyama, and Tadaomi Takenawa (9 February 2001) Science291 (5506), 1047.
[DOI: 10.1126/science.291.5506.1047] |Abstract »|Full Text »|PDF »|Supplemental Data »
REPORTS
Marijn G. J. Ford, Barbara M. F. Pearse, Matthew K. Higgins, Yvonne Vallis, David J. Owen, Adele Gibson, Colin R. Hopkins, Philip R. Evans, and Harvey T. McMahon (9 February 2001) Science291 (5506), 1051.
[DOI: 10.1126/science.291.5506.1051] |Abstract »|Full Text »|PDF »
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