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Science 22 December 2000:
Vol. 290. no. 5500, pp. 2245 - 2247
DOI: 10.1126/science.290.5500.2245
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News Focus

MICROBIOLOGY:
Simple Hosts May Help Reveal How Bacteria Infect Cells

Evelyn Strauss

Important human pathogens invade and harm simple organisms. What's more, these infections require many of the same bacterial genes needed to make mammals sick. These observations suggest that even though simple organisms aren't perfect models for complex hosts such as mammals, the basic mechanisms by which bacteria establish infections in the various organisms may be similar. As a result, the work may help microbiologists identify the host proteins involved in infections, thereby providing potential new targets for antibacterial drugs.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface.
G. W. P. Joshua, A. V. Karlyshev, M. P. Smith, K. E. Isherwood, R. W. Titball, and B. W. Wren (2003)
Microbiology 149, 3221-3229
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Science. ISSN 0036-8075 (print), 1095-9203 (online)