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Science 8 December 2000:
Vol. 290. no. 5498, pp. 1902 - 1903
DOI: 10.1126/science.290.5498.1902
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Perspectives

CELL BIOLOGY:
Actin' Up with Rac1

Nansi Jo Colley

The elegant architecture of photoreceptor cells in the retina is dependent on organization of the actin cytoskeleton during eye development. But what drives this organization? In an equally elegant Perspective, Colley explains new findings in fruit flies (Chang and Ready) that point to the photopigment rhodopsin and its signaling molecule the Rho GTPase Drac1 as the orchestrators of actin organization and the consequent assembly of the sensory membrane in the photoreceptor cell.

The author is in the Department of Ophthalmology and Visual Sciences and Department of Genetics, University of Wisconsin, Madison, WI 53706, USA. E-mail: njcolley{at}facstaff.wisc.edu

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