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Science 8 December 2000:
Vol. 290. no. 5498, p. 1853
DOI: 10.1126/science.290.5498.1853i
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The formation of double-strand breaks (DSB) in DNA leads to the localization of DNA damage sensors such as g-H2AX and NBS1 within the nucleus. Extensive DSB occur during the process of somatic V(D)J recombination required for the generation of T cell and B cell receptors. H. T. Chen et al. (p. 1962), using antibody staining and confocal microscopy, observed that foci of g-H2AX and NBS1 localized at sites corresponding to V(D)J recombination in developing thymocytes. Such foci were not detected in cells in which recombination had ceased or that lacked the enzymatic machinery necessary for DNA recombination. DNA sensors might be recruited to sites of V(D)J recombination as a means of preventing unwanted and potentially oncogenic translocations that could occur during these recombination events.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)