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Science 27 October 2000:
Vol. 290. no. 5492, pp. 721 - 724
DOI: 10.1126/science.290.5492.721
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Perspectives

BIOMEDICINE:
Combating Parkinson's Disease--Step Three

Lars Olson

The degeneration of dopamine neurons in the nigrostriatal pathway of the brain results in the debilitating motor deficits of Parkinson's disease. In a Perspective, Olson discusses a new study (Kordower et al.) demonstrating that injection of a lentiviral vector containing the gene encoding GDNF (a trophic factor for dopamine neurons) into the nigrostriatal pathway of monkeys with PD prevents neuronal loss and reverses some of the motor deficits of this disease.

The author is in the Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden. E-mail: lars.olson{at}neuro.ki.se

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys.
R. Grondin, Z. Zhang, A. Yi, W. A. Cass, N. Maswood, A. H. Andersen, D. D. Elsberry, M. C. Klein, G. A. Gerhardt, and D. M. Gash (2002)
Brain 125, 2191-2201
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Gene Therapy Effective in Primate Model of Parkinson's Disease.
(2000)
Journal Watch Psychiatry 2000, 14
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Gene Therapy Effective in Primate Model of Parkinson's Disease.
(2000)
Journal Watch (General) 2000, 2
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Science. ISSN 0036-8075 (print), 1095-9203 (online)