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Also see the archival list of Science's Compass: Enhanced Perspectives
AIDS: Enhanced: Preventing AIDS But Not HIV-1 Infection with a DNA Vaccine
Xuefei Shen and Robert F. Siliciano
Although there has been some success in treating human immunodeficiency virus (HIV) patients with triple drug therapy (highly active antiretroviral therapy or HAART), the best hope for combating AIDS (the disease caused by HIV) could be a combination of drug therapy and vaccination, according to Shen and Siliciano in their Perspective. A new study in rhesus monkeys treated with a DNA vaccine (Barouch et al.) demonstrates that a powerful vaccine-induced CD8+ cytolytic T cell response reduces the amount of virus in the blood to very low levels preventing the drastic decrease in CD4+ T helper cells and subsequent immunodeficiency. As the Perspective authors explain, vaccinating HIV patients that are receiving HAART may enable HIV levels to be permanently brought under control such that the drug treatment can eventually be stopped.
The authors are in the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: rsilicia{at}welch.jhu.edu
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RESEARCH ARTICLES
Dan H. Barouch, Sampa Santra, Jörn E. Schmitz, Marcelo J. Kuroda, Tong-Ming Fu, Wendeline Wagner, Miroslawa Bilska, Abie Craiu, Xin Xiao Zheng, Georgia R. Krivulka, Kristin Beaudry, Michelle A. Lifton, Christine E. Nickerson, Wendy L. Trigona, Kara Punt, Dan C. Freed, Liming Guan, Sheri Dubey, Danilo Casimiro, Adam Simon, Mary-Ellen Davies, Michael Chastain, Terry B. Strom, Rebecca S. Gelman, David C. Montefiori, Mark G. Lewis, Emilio A. Emini, John W. Shiver, and Norman L. Letvin (20 October 2000) Science290 (5491), 486.
[DOI: 10.1126/science.290.5491.486] |Abstract »|Full Text »|PDF »
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