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Science 20 October 2000:
Vol. 290. no. 5491, pp. 428 - 430
DOI: 10.1126/science.290.5491.428
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News Focus

MALARIA:
A Renewed Assault on an Old and Deadly Foe

Eliot Marshall

After languishing for decades in the scientific backwaters, malaria research is suddenly being swept into the mainstream. Money is beginning to pour in from international finance and aid organizations, giving researchers who have been doggedly pursuing an intractable foe with limited resources the means to follow new leads. But on the ground, the disease is unyielding, and the current weapons are losing their effectiveness.

In a series of related stories, Science explores the World Health Organization's crusade that aims to cut malaria mortality in half over the next 10 years, conditions on the front lines of clinical research in Africa, the challenges that have slowed development of a so-far elusive vaccine, renewed interest in a Chinese herbal remedy that could aid in the fight against drug-resistant malaria, progress in attacking the Plasmodium parasite through its genome, and the dream of building a malaria-proof mosquito.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccine Encoding Thrombospondin-Related Adhesion Protein but Not Circumsporozoite Protein Partially Protects Healthy Malaria-Naive Adults against Plasmodium falciparum Sporozoite Challenge..
S. J. Dunachie, M. Walther, J. E. Epstein, S. Keating, T. Berthoud, L. Andrews, R. F. Andersen, P. Bejon, N. Goonetilleke, I. Poulton, et al. (2006)
Infect. Immun. 74, 5933-5942
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Safety, Immunogenicity, and Efficacy of Prime-Boost Immunization with Recombinant Poxvirus FP9 and Modified Vaccinia Virus Ankara Encoding the Full-Length Plasmodium falciparum Circumsporozoite Protein..
M. Walther, F. M. Thompson, S. Dunachie, S. Keating, S. Todryk, T. Berthoud, L. Andrews, R. F. Andersen, A. Moore, S. C. Gilbert, et al. (2006)
Infect. Immun. 74, 2706-2716
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Prime-boost strategies for malaria vaccine development.
S. J. Dunachie and A. V. S. Hill (2003)
J. Exp. Biol. 206, 3771-3779
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Population Structure of Anopheles gambiae in Africa.
T. Lehmann, M. Licht, N. Elissa, B. T. A. Maega, J. M. Chimumbwa, F. T. Watsenga, C. S. Wondji, F. Simard, and W. A. Hawley (2003)
J. Hered. 94, 133-147
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