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Science 13 October 2000:
Vol. 290. no. 5490, pp. 286 - 287
DOI: 10.1126/science.290.5490.286
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Perspectives

PHOTOCHEMISTRY:
Twist and Fluoresce

John I. Brauman

Catalytic antibodies, or artificial enzymes, act as catalysts by lowering the energy of the transition state of a reaction. In his Perspective, Brauman highlights the study by Simeonov et al., who have applied similar principles to photochemical processes and shown that intense fluorescence can be achieved. The approach provides a way of measuring internal molecular motion within the antibody on a very fast time scale. Fluorescent antibodies may find applications in immunochemistry, histological assays, and genomic studies.

The author is in the Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA. E-mail: brauman{at}stanford.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)