Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Also see the archival list of Science's Compass: Enhanced Perspectives
CANCER: Enhanced: Proximity Matters
John R. K. Savage
Many cancers induced by radiation have characteristic chromosomal abnormalities in which a section of one chromosome becomes fused to or exchanged with a section of another chromosome. It has long been debated whether the points of chromosomal exchange are established before or after radiation damage. Savage comments in his Perspective on new findings (Nikiforova et al.) suggesting that the chromosomal points of exchange are already established before radiation exposure and may be a normal feature of cell differentiation.
The author is at 34 City Road, Tilehurst, Reading RG31 5HB, UK.
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Marina N. Nikiforova, James R. Stringer, Ruthann Blough, Mario Medvedovic, James A. Fagin, and Yuri E. Nikiforov (6 October 2000) Science290 (5489), 138.
[DOI: 10.1126/science.290.5489.138] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential 14-3-3 Affinity Capture Reveals New Downstream Targets of Phosphatidylinositol 3-Kinase Signaling.
F. Dubois, F. Vandermoere, A. Gernez, J. Murphy, R. Toth, S. Chen, K. M. Geraghty, N. A. Morrice, and C. MacKintosh (2009)
Mol. Cell. Proteomics
8, 2487-2499
|Abstract »|Full Text »|PDF »
Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains.
J. A. Aten, J. Stap, P. M. Krawczyk, C. H. van Oven, R. A. Hoebe, J. Essers, and R. Kanaar (2004)
Science
303, 92-95
|Abstract »|Full Text »|PDF »
Chromosomes are predominantly located randomly with respect to each other in interphase human cells.
M. N. Cornforth, K. M. Greulich-Bode, B. D. Loucas, J. Arsuaga, M. Vazquez, R. K. Sachs, M. Bruckner, M. Molls, P. Hahnfeldt, L. Hlatky, et al. (2002)
J. Cell Biol.
159, 237-244
|Abstract »|Full Text »|PDF »
M-FISH analysis shows that complex chromosome aberrations induced by alpha -particle tracks are cumulative products of localized rearrangements.
R. M. Anderson, D. L. Stevens, and D. T. Goodhead (2002)
PNAS
99, 12167-12172
|Abstract »|Full Text »|PDF »
Cancer Genomics: Promises and Complexities.
W. Zhang, P. M. Laborde, K. R. Coombes, D. A. Berry, and S. R. Hamilton (2001)
Clin. Cancer Res.
7, 2159-2167
|Abstract »|Full Text »|PDF »
