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Science 6 October 2000:
Vol. 290. no. 5489, pp. 23 - 25
DOI: 10.1126/science.290.5489.23b
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News of the Week

NEUROSCIENCE:
A Possible Target for Better Benzodiazepines

Laura Helmuth

Pharmacologists have tried for years to distill the desirable effects of benzodiazepines from the undesirable ones; now a team of neuroscientists has shown that such a strategy could well succeed. Benzodiazepines work by amplifying the action of the neurotransmitter GABA, the brain's main "off" switch, and in work described on page 131, a group has pinpointed one particular subtype of the GABA receptor as the source of benzodiazepines' anxiety-reducing powers.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)