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Science 8 September 2000:
Vol. 289. no. 5485, pp. 1670 - 1672
DOI: 10.1126/science.289.5485.1670
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News Focus

MEDICINE:
DNA Arrays Reveal Cancer in Its Many Forms

Jean Marx

The use of microarrays--slides or chips systematically dotted with DNA from thousands of genes--to determine gene expression patterns is providing a wealth of new information that should aid in cancer diagnosis and ultimately in therapy. In the past several months, researchers in several labs have used microarray technology to identify specific subtypes of a variety of cancers, including leukemias and lymphomas, the dangerous skin cancer melanoma, and breast cancer. In some cases, they can determine which cancers are likely to respond to current therapies and which aren't. In addition, the studies are giving researchers a fix on which genes are important for the development, maintenance, and spread of the various cancers, and are thus possible drug targets.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetics 101: detecting mutations in human genes.
A. Sinclair (2002)
Can. Med. Assoc. J. 167, 275-279
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Identification of testis development and spermatogenesis-related genes in human and mouse testes using cDNA arrays.
J. Sha, Z. Zhou, J. Li, L. Yin, H. Yang, G. Hu, M. Luo, H. C. Chan, and K. Zhou (2002)
Mol. Hum. Reprod. 8, 511-517
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Association of Interferon Regulatory Factor-1, Nucleophosmin, Nuclear Factor-{kappa}B, and Cyclic AMP Response Element Binding with Acquired Resistance to Faslodex (ICI 182,780).
Z. Gu, R. Y. Lee, T. C. Skaar, K. B. Bouker, J. N. Welch, J. Lu, A. Liu, Y. Zhu, N. Davis, F. Leonessa, et al. (2002)
Cancer Res. 62, 3428-3437
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Development and Validation of a Method for Using Breast Core Needle Biopsies for Gene Expression Microarray Analyses.
M. Ellis, N. Davis, A. Coop, M. Liu, L. Schumaker, R. Y. Lee, R. Srikanchana, C. G. Russell, B. Singh, W. R. Miller, et al. (2002)
Clin. Cancer Res. 8, 1155-1166
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Expression Profiling of Human Tumors: The End of Surgical Pathology?.
M. Ladanyi, W. C. Chan, T. J. Triche, and W. L. Gerald (2001)
J. Mol. Diagn. 3, 92-97
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Surgical Pathology Versus Molecular Biology.
E. D. Williams and M. Sobrinho-Simoes (2001)
International Journal of Surgical Pathology 9, 1-3
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Science. ISSN 0036-8075 (print), 1095-9203 (online)