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Science 1 September 2000:
Vol. 289. no. 5484, p. 1490
DOI: 10.1126/science.289.5484.1490
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Perspectives

PROTEIN EVOLUTION:
On the Ancestry of Barrels

Edith Wilson Miles and David R. Davies

Most proteins consist of several domains linked together in a single polypeptide chain, and many of these proteins have evolved by gene duplication and fusion. Miles and Davies discuss the study by Lang et al., who show that this type of protein evolution may also occur in b/a barrel proteins, a common single-domain protein fold. Other single domain proteins may have arisen from similar evolutionary mechanisms.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alternative splicing and protein structure evolution.
F. Birzele, G. Csaba, and R. Zimmer (2008)
Nucleic Acids Res. 36, 550-558
   Abstract »    Full Text »    PDF »
Evolution of Ribonuclease Inhibitor by Exon Duplication.
M. C. Haigis, E. S. Haag, and R. T. Raines (2002)
Mol. Biol. Evol. 19, 959-963
   Full Text »    PDF »


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