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Science 1 September 2000:
Vol. 289. no. 5484, pp. 1483 - 1484
DOI: 10.1126/science.289.5484.1483

Perspectives

MICROBIOLOGY:
How to Get Along--Friendly Microbes in a Hostile World

Ramnik J. Xavier and Daniel K. Podolsky

Microbiologists have long been puzzled by the finding that the gut mucosa does not respond to the myriad varieties of bacteria that normally reside in the gut. As Xavier and Podolsky explain in their Perspective, this may be because bacteria that are indigenous to the gut have learned ways to switch off pathways in gut epithelial cells that lead to switching on of genes involved in inflammation (Neish et al.).

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E-Letters:

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Microbial Virulence: Don't Forget the Host
Liise-anne Pirofski and Arturo Casadevall
Science Online, 21 Sep 2000 [Full text]



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