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Science 1 September 2000:
Vol. 289. no. 5484, pp. 1446 - 1447
DOI: 10.1126/science.289.5484.1446
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News of the Week

LIPID RESEARCH:
Possible New Way to Lower Cholesterol

Dan Ferber

Clinicians may soon be able to mount a multipronged attack against cholesterol, the artery-clogging lipid whose buildup in the body is a major contributor to heart attacks and other cardiovascular diseases. In work reported on page 1524, a team has pinpointed a biological master switch in mice that controls three pathways that work together to both rid the body of excess cholesterol and prevent its absorption from the intestine. The work suggests a new mechanism for reducing cholesterol, for example, with drugs that turn up the activity of the master switch, a protein known as the retinoid X receptor.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cross-talk between Thyroid Hormone Receptor and Liver X Receptor Regulatory Pathways Is Revealed in a Thyroid Hormone Resistance Mouse Model.
K. Hashimoto, R. N. Cohen, M. Yamada, K. R. Markan, T. Monden, T. Satoh, M. Mori, and F. E. Wondisford (2006)
J. Biol. Chem. 281, 295-302
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Science. ISSN 0036-8075 (print), 1095-9203 (online)