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APOPTOSIS: Mitochondria--the Death Signal Integrators
Catherine Brenner and Guido Kroemer
Many of the intricate pathways of apoptosis that instruct a cell to kill itself involve the convergence of key proteins on the membranes of mitochondria. Such proteins induce the permeabilization of mitochondrial membranes and the release of caspase enzymes and nuclease activators that set in motion the final stages of programmed cell death. Now, as Brenner and Kroemer discuss in their Perspective, a proapoptotic transcription factor called TR3 has been found to move from its normal location in the nucleus to the mitochondria and to promote release of cytochrome c, a key event in apoptosis (Li et al.)
The authors are at the Apoptosis, Cancer and Immunity Laboratory associated with the National League Against Cancer, CNRS-UMR1599, Institut Gustave Roussy, 39 rue Calmette Desmoulins, F-94805 Villejuif, France. C. Brenner is also at CNRS-UMR6022, Université de Technologie de Compiègne, BP 20529, F-60205 Compiègne, France. E-mail: catherine.brenner{at}utc.fr; kroemer{at}igr.fr
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Hui Li, Siva Kumar Kolluri, Jian Gu, Marcia I. Dawson, Xihua Cao, Peter D. Hobbs, Bingzhen Lin, Guo-quen Chen, Jiang-song Lu, Feng Lin, Zhihua Xie, Joseph A. Fontana, John C. Reed, and Xiao-kun Zhang (18 August 2000) Science289 (5482), 1159.
[DOI: 10.1126/science.289.5482.1159] |Abstract »|Full Text »|PDF »
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