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Science 4 August 2000:
Vol. 289. no. 5480, pp. 735 - 736
DOI: 10.1126/science.289.5480.735
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Perspectives

CELL CYCLE:
Replication Meets Cohesion

Kohta Takahashi and Mitsuhiro Yanagida

When a cell replicates its DNA during S phase of the cell cycle, the sister chromatid pairs must stick together like glue until they are separated to opposite ends of the cell (and hence into separate daughter cells) at anaphase. How the cell achieves this is still unclear but, as Takahashi and Yanagida explain in their Perspective, new findings in yeast have identified one molecule, Trf4p, that may be involved both in DNA replication and sister chromatid cohesion (Wang et al.).

The authors are in the Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. E-mail: yanagida{at}kozo.biophys.kyoto-u.ac.jp

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure/Function Analysis of the Saccharomyces cerevisiae Trf4/Pol {sigma} DNA Polymerase.
Z. Wang, I. B. Castano, C. Adams, C. Vu, D. Fitzhugh, and M. F. Christman (2002)
Genetics 160, 381-391
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae CTF18 and CTF4 Are Required for Sister Chromatid Cohesion.
J. S. Hanna, E. S. Kroll, V. Lundblad, and F. A. Spencer (2001)
Mol. Cell. Biol. 21, 3144-3158
   Abstract »    Full Text »

E-Letters:

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Too Many Pol Kappa Enzymes
Errol C. Friedberg
Science Online, 7 Sep 2000 [Full text]

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