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Science 4 August 2000:
Vol. 289. no. 5480, pp. 706 - 707
DOI: 10.1126/science.289.5480.706
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News of the Week

CLINICAL RESEARCH:
Flawed Cancer Study Leads to Shake-Up at University of Oklahoma

David Malakoff

Allegations of lax safety procedures and flawed management in a clinical cancer trial have cost four researchers and administrators their jobs at the University of Oklahoma. They have also led to a temporary shutdown of 75 clinical trials at the university's Health Science Center in Tulsa and a sweeping overhaul of the school's process for approving human experiments. University officials emphasize that none of the roughly 100 patients involved in the 3-year-old study of an experimental cancer vaccine was known to have been harmed, and that most trials will soon be restarted.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Institutional Review Board dilemma: responsible for safety monitoring but not in control.
D. L DeMets, N. Fost, and M. Powers (2006)
Clinical Trials 3, 142-148
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Science. ISSN 0036-8075 (print), 1095-9203 (online)