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Science 28 July 2000:
Vol. 289. no. 5479, pp. 536 - 537
DOI: 10.1126/science.289.5479.536
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News Focus

TOXICOGENOMICS:
Toxicologists Brace for Genomics Revolution

Richard A. Lovett

ASPEN, COLORADO--According to researchers who gathered here at a high-powered summit this month, toxicology may be on the verge of changing the way it collects raw data--adopting a process that could reduce animal use and improve test results. The new approach, called "toxicogenomics," uses DNA arrays to profile gene expression in cells exposed to test compounds. But some leaders in the field warn against rushing too quickly to embrace DNA tests, which are still difficult to interpret.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate.
R. A. Currie, V. Bombail, J. D. Oliver, D. J. Moore, F. L. Lim, V. Gwilliam, I. Kimber, K. Chipman, J. G. Moggs, and G. Orphanides (2005)
Toxicol. Sci. 86, 453-469
   Abstract »    Full Text »    PDF »
The Emergence of Toxicogenomics: A Case Study of Molecularization.
S. Shostak (2005)
Social Studies of Science 35, 367-403
   Abstract »    PDF »
Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling.
J. H. M. van Delft, E. van Agen, S. G. J. van Breda, M. H. Herwijnen, Y. C. M. Staal, and J. C. S. Kleinjans (2004)
Carcinogenesis 25, 1265-1276
   Abstract »    Full Text »    PDF »
Gene Expression in Two Hepatic Cell Lines, Cultured Primary Hepatocytes, and Liver Slices Compared to the in Vivo Liver Gene Expression in Rats: Possible Implications for Toxicogenomics Use of in Vitro Systems.
F. Boess, M. Kamber, S. Romer, R. Gasser, D. Muller, S. Albertini, and L. Suter (2003)
Toxicol. Sci. 73, 386-402
   Abstract »    Full Text »    PDF »
Prediction of Compound Signature Using High Density Gene Expression Profiling.
H. K. Hamadeh, P. R. Bushel, S. Jayadev, O. DiSorbo, L. Bennett, L. Li, R. Tennant, R. Stoll, J. C. Barrett, R. S. Paules, et al. (2002)
Toxicol. Sci. 67, 232-240
   Abstract »    Full Text »    PDF »
A Bold New Direction for Environmental Health Research.
K. Olden, J. Guthrie, and S. Newton (2001)
Am J Public Health 91, 1964-1967
   Abstract »    Full Text »    PDF »
Unique Gene Expression Patterns in Liver and Kidney Associated with Exposure to Chemical Toxicants.
M. J. Bartosiewicz, D. Jenkins, S. Penn, J. Emery, and A. Buckpitt (2001)
J. Pharmacol. Exp. Ther. 297, 895-905
   Abstract »    Full Text »
Analysis of Genetic and Epigenetic Mechanisms of Toxicity: Potential Roles of Toxicogenomics and Proteomics in Toxicology.
S. W. Burchiel, C. M. Knall, J. W. Davis II, R. S. Paules, S. E. Boggs, and C. A. Afshari (2001)
Toxicol. Sci. 59, 193-195
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)