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Science 21 July 2000:
Vol. 289. no. 5478, pp. 403 - 404
DOI: 10.1126/science.289.5478.403
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Perspectives

CELL BIOLOGY:
ER-to-Golgi Traffic--This Bud's for You

Elizabeth E. Brittle and M. Gerard Waters

How do protein-transporting vesicles, which bud from the endoplasmic reticulum (ER), specifically dock to, and fuse with, the Golgi apparatus? In their Perspective, Brittle and Waters discuss new work (Allan et al.) suggesting that some vesicle-associated docking and fusion proteins are "programmed" during vesicle budding from the ER and direct downstream events that occur during fusion of these transport vesicles with the membranes of the Golgi.

The authors are in the Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. E-mail: gwaters{at}molbio.princeton.edu

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