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Science 21 July 2000:
Vol. 289. no. 5478, pp. 401 - 402
DOI: 10.1126/science.289.5478.401
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Perspectives

RNA STRUCTURE:
Ribozyme Evolution at the Crossroads

Gerald F. Joyce

Molecules that have similar sequences usually adopt the same structures and have the same functions. In his Perspective, Joyce explains that this is not always the case. In a remarkable study (Schultes and Bartel), an RNA sequence has been designed that can adopt two different structures, each with a different catalytic function. Joyce details how this study sheds light on the evolution of enzymes.

The author is in the Departments of Chemistry and Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. E-mail: gjoyce{at}scripps.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)