DEVELOPMENTAL BIOLOGY: Why Chicks Aren't All Thumbs

doi:10.1126/science.289.5478.372

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Science 21 July 2000:
Vol. 289. no. 5478, pp. 372 - 373
DOI: 10.1126/science.289.5478.372

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DEVELOPMENTAL BIOLOGY:
Why Chicks Aren't All Thumbs

Michael Hagmann

A new study on page 438 offers some surprising insights on when and how digits assume their distinctive shapes. Scientists had thought that even before cartilage cells begin to develop into a finger or toe, they already know what shape digit to make. The new findings, however, suggest that digit identity is programmed much later in development, by chemical messengers from the surrounding tissue.

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In Science Magazine

LETTERS Fingering Digit Identity: Stuart A. Newman, Randall D. Dahn, and John F. Fallon (13 October 2000)
Science 290 (5490), 275. [DOI: 10.1126/science.290.5490.275]
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REPORTS Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling: Randall D. Dahn and John F. Fallon (21 July 2000)
Science 289 (5478), 438. [DOI: 10.1126/science.289.5478.438]
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