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Science 7 July 2000:
Vol. 289. no. 5476, pp. 67 - 69
DOI: 10.1126/science.289.5476.67
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Perspectives

CELL BIOLOGY:
Travel Bulletin--Traffic Jams Cause Tumors

Mark Peifer

All animal cells have a polarity, that is, different proteins are clustered in distinct domains of the plasma membrane and these regions carry out different jobs. As Peifer discusses in a lively Perspective, new work (Bilder et al.) identifies some of the molecular characters that direct proteins to their different cellular destinations.

The author is in the Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. E-mail: peifer{at}unc.edu

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