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Science 30 June 2000:
Vol. 288. no. 5475, pp. 2304 - 2307
DOI: 10.1126/science.288.5475.2304
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News Focus

HUMAN GENOME:
Finally, the Book of Life and Instructions for Navigating It

Elizabeth Pennisi

The race is over. On 26 June, to much fanfare, two rival teams announced that they had each completed a version of the "book of life"--a rough draft of the complete human genetic code. So what, exactly, is in these two different volumes, and how will they fine-tune it so that everyone from workaday biologists to pharmaceutical giants can mine its gold?

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes.
P. Jones, K. Chase, A. Martin, P. Davern, E. A. Ostrander, and K. G. Lark (2008)
Genetics 179, 1033-1044
   Abstract »    Full Text »    PDF »
The canine genome.
E. A. Ostrander and R. K. Wayne (2005)
Genome Res. 15, 1706-1716
   Abstract »    Full Text »    PDF »
Ethical Issues in Human Genome Epidemiology: A Case Study Based on The Japanese American Family Study in Seattle, Washington.
M. A. Austin (2002)
Am. J. Epidemiol. 155, 585-592
   Abstract »    Full Text »    PDF »
Automated Construction of High-Density Comparative Maps Between Rat, Human, and Mouse.
A. E. Kwitek, P. J. Tonellato, D. Chen, J. Gullings-Handley, Y. S. Cheng, S. Twigger, T. E. Scheetz, T. L. Casavant, M. Stoll, M. A. Nobrega, et al. (2001)
Genome Res. 11, 1935-1943
   Abstract »    Full Text »    PDF »
A Sequence-Based Integrated Map of Chromosome 22.
W. J. Tapper, N. E. Morton, I. Dunham, X. Ke, and A. Collins (2001)
Genome Res. 11, 1290-1295
   Abstract »    Full Text »    PDF »
Molecular Imaging.
R. Weissleder and U. Mahmood (2001)
Radiology 219, 316-333
   Abstract »    Full Text »
Muscular Dystrophy Meets the Gene Chip: New Insights into Disease Pathogenesis.
J. S. Chamberlain (2000)
J. Cell Biol. 151, f43-f46
   Full Text »    PDF »
Toxicogenomics-Based Discrimination of Toxic Mechanism in HepG2 Human Hepatoma Cells.
M. E. Burczynski, M. McMillian, J. Ciervo, L. Li, J. B. Parker, R. T. Dunn II, S. Hicken, S. Farr, and M. D. Johnson (2000)
Toxicol. Sci. 58, 399-415
   Abstract »    Full Text »    PDF »
Design of Retroviral Vectors and Helper Cells for Gene Therapy.
W.-S. Hu and V. K. Pathak (2000)
Pharmacol. Rev. 52, 493-512
   Abstract »    Full Text »    PDF »


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