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Science 23 June 2000:
Vol. 288. no. 5474, pp. 2142 - 2143
DOI: 10.1126/science.288.5474.2142
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Perspectives

DEVELOPMENT:
A Degrading Way to Make an Organ

Jeff Hardin

Working out how organs form during embryonic development is a fascinating area of research. In a witty Perspective, Jeff Hardin describes new findings (Nishiwaki et al.) that reveal the many intricate steps needed for gonads to form in the worm C. elegans. Two key players, GON-1 and MIG-17, are metalloproteases that may help migration of distal tip cells by degrading extracellular matrix components.

The author is in the Department of Zoology and Program in Cellular and Molecular Biology, University of Wisconsin, 1117 West Johnson Street, Madison, WI 53706, USA. E-mail: jdhardin{at}facstaff.wisc.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)