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Science 19 May 2000:
Vol. 288. no. 5469, pp. 1160 - 1161
DOI: 10.1126/science.288.5469.1160
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News Focus

GENETICS:
Zebrafish Earns Its Stripes in Genetic Screens

Gretchen Vogel

COLD SPRING HARBOR, NEW YORK--Because it is a vertebrate, the zebrafish is genetically closer to humans than flies or worms, and its small size, quick generation time, and inexpensive care make it possible to keep thousands of fish in a single lab. Add to that the transparency of its young, and you have what some consider an ideal lab animal. As was demonstrated at a recent meeting here, researchers are using various clever techniques to identify zebrafish mutants with which to probe the genes involved in a wide variety of human maladies, from obesity to bone diseases.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies.
T. X. Liu, Y. Zhou, J. P. Kanki, M. Deng, J. Rhodes, H. W. Yang, X. M. Sheng, L. I. Zon, and A. T. Look (2002)
PNAS 99, 6136-6141
   Abstract »    Full Text »    PDF »
Zebrafish: bridging the gap between development and disease.
A. Dodd, P. M. Curtis, L. C. Williams, and D. R. Love (2000)
Hum. Mol. Genet. 9, 2443-2449
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)