Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 May 2000:
Vol. 288. no. 5467, p. 773
DOI: 10.1126/science.288.5467.773a
Prev | Table of Contents | Next

Editors' Choice: Highlights of the recent literature

A series of articles describe the results of the Drosophila Genome Annotation Assessment Project (www.fruitfly.org/GASP/), a collaboration of 12 research groups formed to evaluate computational tools currently available for the analysis of genome sequence. All of these groups were examining the same sequence, 2.9 Mb centered on the Adh gene of Drosophila. This region has been studied extensively for 20 years and is known to include genes of varying complexity, including one with 30 exons and some that were located within the introns of other genes. The groups used computer programs to develop predictions based on ab initio gene identification, promoter recognition, EST and cDNA alignment, protein similarity, repetitive sequence identification, and gene function.

Stormo describes the basic principles of genome annotation; Reese et al. present an overview of how the project was designed and how results were evaluated; and Ashburner presents a summary of the findings, from the expected to the surprising. -- BJ

Genome Res.10 (2000).

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)