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Science 17 March 2000:
Vol. 287. no. 5460, pp. 1898 - 1899
DOI: 10.1126/science.287.5460.1898
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News of the Week

HUMAN GENOME RESEARCH:
SNP Mappers Confront Reality and Find It Daunting

Leslie Roberts

The genetic markers called SNPs have been widely touted as the key to personalized medicine, with drugs tailored to an individual's genotype and simple tests to determine one's risk of specific diseases. But a closed meeting held last week, sponsored by the SNP Consortium and the U.S. National Human Genome Research Institute, concluded that those promises may be harder to achieve than expected, and that more SNPs may be required to track down a particular disease gene than previously estimated.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High throughput parallel synthesis of oligonucleotides with 1536 channel synthesizer.
J.-Y. Cheng, H.-H. Chen, Y.-S. Kao, W.-C. Kao, and K. Peck (2002)
Nucleic Acids Res. 30, e93
   Abstract »    Full Text »    PDF »
Duplex Scorpion primers in SNP analysis and FRET applications.
A. Solinas, L. J. Brown, C. McKeen, J. M. Mellor, J. Nicol, N. Thelwell, and T. Brown (2001)
Nucleic Acids Res. 29, e96
   Abstract »    Full Text »    PDF »
A cSNP Map and Database for Human Chromosome 21.
S. Deutsch, C. Iseli, P. Bucher, S. E. Antonarakis, and H. S. Scott (2001)
Genome Res. 11, 300-307
   Abstract »    Full Text »
Mode of action and application of Scorpion primers to mutation detection.
N. Thelwell, S. Millington, A. Solinas, J. Booth, and T. Brown (2000)
Nucleic Acids Res. 28, 3752-3761
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)