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Science 10 March 2000:
Vol. 287. no. 5459, pp. 1777 - 1782
DOI: 10.1126/science.287.5459.1777
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Pathways of Discovery
GENOMICS:
Journey to the Center of Biology
Eric S. Lander and Robert A. Weinberg*
According to Eric Lander and Robert Weinberg, the greatest achievement in biology over the past millennium has been the elucidation of the mechanism of heredity. In this month's essay, they chronicle this scientific adventure and its implications for 21st century biology. Their widely accessible tale spans from Gregor Mendel's 19th century pea experiments, to the discovery of DNA, to today's extraordinarily revealing arena of genomic science and technology.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- In Search of True-Breeding Hybrids.
- W. D. Stansfield (2008)
J. Hered.
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- Osmogenetics: Aristotle to Arabidopsis.
- A. Maggio, J.-K. Zhu, P. M. Hasegawa, and R. A. Bressan (2006)
PLANT CELL
18, 1542-1557
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- Academic Medical Centers and Medical Research: The Challenges Ahead.
- J. J. Cohen and E. K. Siegel (2005)
JAMA
294, 1367-1372
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- Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans.
- T. A. Greenwood, P. E. Cadman, M. Stridsberg, S. Nguyen, L. Taupenot, N. J. Schork, and D. T. O'Connor (2004)
Physiol Genomics
18, 119-127
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| Full Text »
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- Large-Scale Integration of Human Genetic and Physical Maps.
- C. M. Nievergelt, D. W. Smith, J. B. Kohlenberg, and N. J. Schork (2004)
Genome Res.
14, 1199-1205
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| Full Text »
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- Identifying genes and genetic variation underlying human diseases and complex phenotypes via recombination mapping.
- U. Broeckel and N. J. Schork (2004)
J. Physiol.
554, 40-45
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| Full Text »
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- A General Statistical Framework for Mapping Quantitative Trait Loci in Nonmodel Systems: Issue for Characterizing Linkage Phases.
- M. Lin, X.-Y. Lou, M. Chang, and R. Wu (2003)
Genetics
165, 901-913
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| Full Text »
| PDF »
- Genome-Wide In Silico Identification of Transcriptional Regulators Controlling the Cell Cycle in Human Cells.
- R. Elkon, C. Linhart, R. Sharan, R. Shamir, and Y. Shiloh (2003)
Genome Res.
13, 773-780
| Abstract »
| Full Text »
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- 2001 W.O. Atwater Memorial Lecture and the 2001 ASNS President's Lecture: Human Nutrient Requirements: The Challenge of the Post-Genome Era.
- V. R. Young (2002)
J. Nutr.
132, 621-629
| Full Text »
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- Learning from the Arabidopsis Experience. The Next Gene Search Paradigm.
- R. A. Bressan, C. Zhang, H. Zhang, P. M. Hasegawa, H. J. Bohnert, and J.-K. Zhu (2001)
Plant Physiology
127, 1354-1360
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- Cancer Genomics: Promises and Complexities.
- W. Zhang, P. M. Laborde, K. R. Coombes, D. A. Berry, and S. R. Hamilton (2001)
Clin. Cancer Res.
7, 2159-2167
| Abstract »
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- Genomic Medicine and the Individual Patient--Byte to Bedside: A Call for Papers.
- C. D. DeAngelis, R. N. Rosenberg, and J. M. Smith (2001)
Arch Dermatol
137, 218
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- Genomic Medicine and the Individual Patient--Byte to Bedside: A Call for Papers.
- C. D. DeAngelis, R. N. Rosenberg, and J. M. Smith (2001)
Arch Pediatr Adolesc Med
155, 116
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- Genetic Research and Nutritional Individuality.
- R. B. Eckhardt (2001)
J. Nutr.
131, 336S-339
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- Genomic Medicine and the Individual Patient--Byte to Bedside: A Call for Papers.
- C. D. DeAngelis, R. N. Rosenberg, and J. M. Smith (2001)
Arch Intern Med
161, 151
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- Genomic Medicine and the Individual Patient--Byte to Bedside: A Call for Papers.
- C. D. DeAngelis, R. N. Rosenberg, and J. M. Smith (2000)
JAMA
284, 2642
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- Functional Assignment of the 20 S Proteasome from Trypanosoma brucei Using Mass Spectrometry and New Bioinformatics Approaches.
- L. Huang, R. J. Jacob, S. C.-H. Pegg, M. A. Baldwin, C. C. Wang, A. L. Burlingame, and P. C. Babbitt (2001)
J. Biol. Chem.
276, 28327-28339
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