Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Also see the archival list of Science's Compass: Enhanced Perspectives
MICROBIOLOGY: Enhanced: A Furtive Pathogen Revealed
Xavier Nassif
The pathogenic bacterium Neisseria meningitidis is the cause of meningococcal meningitis. Although a vaccine is available for Neisseria of serogroups A and C, there is no vaccine available for serogroup B. In a Perspective, Nassif reports on the sequencing of the complete genome of N. meningitidis type B strain MC58 (Tettelin et al.) and the mining of this genome to identify highly conserved surface proteins that may be valuable as vaccine antigens (Pizza et al.).
The author is at INSERM Unit 411, Faculté de Médecine Necker-Enfants Malades, 156 Rue de Vaugirard, 75015 Paris, France. E-mail: nassif{at}necker.fr
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Hervé Tettelin, Nigel J. Saunders, John Heidelberg, Alex C. Jeffries, Karen E. Nelson, Jonathan A. Eisen, Karen A. Ketchum, Derek W. Hood, John F. Peden, Robert J. Dodson, William C. Nelson, Michelle L. Gwinn, Robert DeBoy, Jeremy D. Peterson, Erin K. Hickey, Daniel H. Haft, Steven L. Salzberg, Owen White, Robert D. Fleischmann, Brian A. Dougherty, Tanya Mason, Anne Ciecko, Debbie S. Parksey, Eric Blair, Henry Cittone, Emily B. Clark, Matthew D. Cotton, Terry R. Utterback, Hoda Khouri, Haiying Qin, Jessica Vamathevan, John Gill, Vincenzo Scarlato, Vega Masignani, Mariagrazia Pizza, Guido Grandi, Li Sun, Hamilton O. Smith, Claire M. Fraser, E. Richard Moxon, Rino Rappuoli, and J. Craig Venter (10 March 2000) Science287 (5459), 1809.
[DOI: 10.1126/science.287.5459.1809] |Abstract »|Full Text »|PDF »
REPORTS
Mariagrazia Pizza, Vincenzo Scarlato, Vega Masignani, Marzia Monica Giuliani, Beatrice Aricò, Maurizio Comanducci, Gary T. Jennings, Lucia Baldi, Erika Bartolini, Barbara Capecchi, Cesira L. Galeotti, Enrico Luzzi, Roberto Manetti, Elisa Marchetti, Marirosa Mora, Sandra Nuti, Giulio Ratti, Laura Santini, Silvana Savino, Maria Scarselli, Elisa Storni, Peijun Zuo, Michael Broeker, Erika Hundt, Bernard Knapp, Eric Blair, Tanya Mason, Hervé Tettelin, Derek W. Hood, Alex C. Jeffries, Nigel J. Saunders, Dan M. Granoff, J. Craig Venter, E. Richard Moxon, Guido Grandi, and Rino Rappuoli (10 March 2000) Science287 (5459), 1816.
[DOI: 10.1126/science.287.5459.1816] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086.
A. Mascioni, B. E. Bentley, R. Camarda, D. A. Dilts, P. Fink, V. Gusarova, S. K. Hoiseth, J. Jacob, S. L. Lin, K. Malakian, et al. (2009)
J. Biol. Chem.
284, 8738-8746
|Abstract »|Full Text »|PDF »
Two centuries of meningococcal infection: from Vieusseux to the cellular and molecular basis of disease.
Stroke Secondary to Meningococcal Meningitidis: A Potential Link Between Endothelial Dysfunction and Cytokines.
A. Leite de Souza and A. C. Seguro (2008)
Arch Neurol
65, 283-284
|Full Text »|PDF »
Human and Bovine Milk Oligosaccharides Inhibit Neisseria meningitidis Pili Attachment In Vitro.
J. Hakkarainen, M. Toivanen, A. Leinonen, L. Frangsmyr, N. Stromberg, S. Lapinjoki, X. Nassif, and C. Tikkanen-Kaukanen (2005)
J. Nutr.
135, 2445-2448
|Abstract »|Full Text »|PDF »
