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Science 18 February 2000:
Vol. 287. no. 5456, pp. 1179 - 1181
DOI: 10.1126/science.287.5456.1179
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News of the Week

GENOMICS:
Mouse Sequencers Take Up the Shotgun

Elizabeth Pennisi

MARCO ISLAND, FLORIDA--In a dramatic departure, the genome community will be using a controversial sequencing strategy--one that many scientists have publicly trounced--to tackle its next big target: the mouse. Discussions at a meeting held here last week made clear that a good part of the mouse will be sequenced using the whole-genome shotgun method pioneered by J. Craig Venter of Celera Genomics in Rockville, Maryland. But it will be used in combination with the more incremental strategy used by the Human Genome Project, the publicly funded consortium sequencing the human genome and the genomes of other organisms.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High-Resolution BAC-Based Map of the Central Portion of Mouse Chromosome 5.
J. Crabtree, T. Wiltshire, B. Brunk, S. Zhao, J. Schug, C. J. Stoeckert Jr., and M. Bucan (2001)
Genome Res. 11, 1746-1757
   Abstract »    Full Text »    PDF »
Toxicogenomics-Based Discrimination of Toxic Mechanism in HepG2 Human Hepatoma Cells.
M. E. Burczynski, M. McMillian, J. Ciervo, L. Li, J. B. Parker, R. T. Dunn II, S. Hicken, S. Farr, and M. D. Johnson (2000)
Toxicol. Sci. 58, 399-415
   Abstract »    Full Text »    PDF »


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