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Science 11 February 2000:
Vol. 287. no. 5455, pp. 959 - 960
DOI: 10.1126/science.287.5455.959
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News Focus

AIDS RESEARCH:
Vaccine Studies Stymied by Shortage of Animals

Jon Cohen

The National Institutes of Health doesn't know how many Indian rhesus macaques its researchers need, nor how many are available. That's a big problem for AIDS researchers, because the macaques provide the only good animal model researchers have for testing vaccines, measuring the toxicity of various drugs, and exploring the disease's progression. The shortage of rhesus macaques has highlighted the need for scientists to become more involved in breeding them.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disease modeling for Ebola and Marburg viruses.
D. Bente, J. Gren, J. E. Strong, and H. Feldmann (2009)
Dis. Model. Mech. 2, 12-17
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The High Frequency Indian Rhesus Macaque MHC Class I Molecule, Mamu-B*01, Does Not Appear to Be Involved in CD8+ T Lymphocyte Responses to SIVmac239.
J. T. Loffredo, J. Sidney, S. Piaskowski, A. Szymanski, J. Furlott, R. Rudersdorf, J. Reed, B. Peters, H. D. Hickman-Miller, W. Bardet, et al. (2005)
J. Immunol. 175, 5986-5997
   Abstract »    Full Text »    PDF »
Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques.
K. C. Krebs, Z. Jin, R. Rudersdorf, A. L. Hughes, and D. H. O'Connor (2005)
J. Immunol. 175, 5230-5239
   Abstract »    Full Text »    PDF »
Use of Assisted Reproductive Technologies in the Propagation of Rhesus Macaque Offspring.
D.P. Wolf, S. Thormahlen, C. Ramsey, R.R. Yeoman, J. Fanton, and S. Mitalipov (2004)
Biol Reprod 71, 486-493
   Abstract »    Full Text »    PDF »
Infectious Agent and Immune Response Characteristics of Chronic Enterocolitis in Captive Rhesus Macaques.
K. Sestak, C. K. Merritt, J. Borda, E. Saylor, S. R. Schwamberger, F. Cogswell, E. S. Didier, P. J. Didier, G. Plauche, R. P. Bohm, et al. (2003)
Infect. Immun. 71, 4079-4086
   Abstract »    Full Text »    PDF »
Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques.
J. L. Huff, R. Eberle, J. Capitanio, S. S. Zhou, and P. A. Barry (2003)
J. Gen. Virol. 84, 83-92
   Abstract »    Full Text »    PDF »
Monozygotic Twinning in Rhesus Monkeys by Manipulation of In Vitro-Derived Embryos.
S. M. Mitalipov, R. R. Yeoman, H.-C. Kuo, and D. P. Wolf (2002)
Biol Reprod 66, 1449-1455
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)