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Science 21 January 2000:
Vol. 287. no. 5452, pp. 451 - 452
DOI: 10.1126/science.287.5452.451
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Tech.Sight

MOLECULAR BIOLOGY:
Bead-based Fiber-Optic Arrays

David R. Walt

Standard DNA microarray technology has revolutionized the large-scale study of gene expression and genotyping. In this TechView, David Walt discusses the design of a new microarray technology that uses etched optical fibers and microspheres tagged with fluorescent DNA probes.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fiber-Optic Microarray for Simultaneous Detection of Multiple Harmful Algal Bloom Species.
S. Ahn, D. M. Kulis, D. L. Erdner, D. M. Anderson, and D. R. Walt (2006)
Appl. Envir. Microbiol. 72, 5742-5749
   Abstract »    Full Text »    PDF »
Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens..
H.-R. Li, J. Wang-Rodriguez, T. M. Nair, J. M. Yeakley, Y.-S. Kwon, M. Bibikova, C. Zheng, L. Zhou, K. Zhang, T. Downs, et al. (2006)
Cancer Res. 66, 4079-4088
   Abstract »    Full Text »    PDF »
A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods.
K. Hao, X. Wang, T. Niu, X. Xu, A. Li, W. Chang, L. Wang, G. Li, N. Laird, and X. Xu (2004)
Hum. Mol. Genet. 13, 683-691
   Abstract »    Full Text »    PDF »
From The Cover: Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize.
H. Shou, P. Bordallo, J.-B. Fan, J. M. Yeakley, M. Bibikova, J. Sheen, and K. Wang (2004)
PNAS 101, 3298-3303
   Abstract »    Full Text »    PDF »
Direct measurement of the melting temperature of supported DNA by electrochemical method.
R. Meunier-Prest, S. Raveau, E. Finot, G. Legay, M. Cherkaoui-Malki, and N. Latruffe (2003)
Nucleic Acids Res. 31, e150
   Abstract »    Full Text »    PDF »
Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection.
Y. C. Cao, R. Jin, and C. A. Mirkin (2002)
Science 297, 1536-1540
   Abstract »    Full Text »    PDF »
DNA probes on beads arrayed in a capillary, 'Bead-array', exhibited high hybridization performance.
Y. Kohara, H. Noda, K. Okano, and H. Kambara (2002)
Nucleic Acids Res. 30, e87
   Abstract »    Full Text »    PDF »
Submicrometer Metallic Barcodes.
S. R. Nicewarner-Pena, R. G. Freeman, B. D. Reiss, L. He, D. J. Pena, I. D. Walton, R. Cromer, C. D. Keating, and M. J. Natan (2001)
Science 294, 137-141
   Abstract »    Full Text »    PDF »
Automation for Genomics, Part Two: Sequencers, Microarrays, and Future Trends.
D. Meldrum (2000)
Genome Res. 10, 1288-1303
   Abstract »    Full Text »


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