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Science 24 December 1999:
Vol. 286. no. 5449, pp. 2441 - 2442
DOI: 10.1126/science.286.5449.2441
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News Focus

BIOCHEMISTRY:
DNA Cuts Its Teeth--As an Enzyme

Elizabeth Finkel

Researchers now have a new class of molecules for inactivating genes: DNA enzymes, which can bind to and cleave the genes' RNA messages. No DNA enzymes are known in nature, however, and so they have mainly been laboratory curiosities. But in work reported in the November issue of Nature Medicine, researchers showed that a DNA enzyme can slow the narrowing of coronary arteries that have been opened with balloon angioplasty in a rat model of heart disease.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A novel replicating circular DNAzyme.
F. Chen, R. Wang, Z. Li, B. Liu, X. Wang, Y. Sun, D. Hao, and J. Zhang (2004)
Nucleic Acids Res. 32, 2336-2341
   Abstract »    Full Text »    PDF »
Angiogenic Inhibition Mediated by a DNAzyme That Targets Vascular Endothelial Growth Factor Receptor 2.
L. Zhang, W. J. Gasper, S. A. Stass, O. B. Ioffe, M. A. Davis, and A. J. Mixson (2002)
Cancer Res. 62, 5463-5469
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)