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Science 17 December 1999:
Vol. 286. no. 5448, pp. 2256 - 2258
DOI: 10.1126/science.286.5448.2256
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News Focus

BIOMEDICINE:
Does Cancer Therapy Trigger Cell Suicide?

Elizabeth Finkel

The notion that drugs and radiation kill cancer cells by causing them to self-destruct has guided drug searches for the past few years. But some cancer experts aren't convinced that this is the case, at least not for solid tumors such as cancers of the lung, breast, prostate, and colon. They say that the kinds of test tube assays that point to apoptosis, as cell suicide is more technically called, as critical to cancer therapy may not accurately reflect what happens in cancers that have developed naturally in the body. What's more, they argue, using assays based on apoptosis to screen for cancer drugs might cause researchers to miss drugs that kill by other means.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cells with Defective p53-p21-pRb Pathway Are Susceptible to Apoptosis Induced by p84N5 via Caspase-6.
E. Garner, F. Martinon, J. Tschopp, P. Beard, and K. Raj (2007)
Cancer Res. 67, 7631-7637
   Abstract »    Full Text »    PDF »
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.
S. Rottenberg, A. O. H. Nygren, M. Pajic, F. W. B. van Leeuwen, I. van der Heijden, K. van de Wetering, X. Liu, K. E. de Visser, K. G. Gilhuijs, O. van Tellingen, et al. (2007)
PNAS 104, 12117-12122
   Abstract »    Full Text »    PDF »
Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition.
K. Latha, W. Zhang, N. Cella, H. Y. Shi, and M. Zhang (2005)
Mol. Cell. Biol. 25, 1737-1748
   Abstract »    Full Text »    PDF »
Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.
Y. Suarez, L. Gonzalez, A. Cuadrado, M. Berciano, M. Lafarga, and A. Munoz (2003)
Mol. Cancer Ther. 2, 863-872
   Abstract »    Full Text »    PDF »
Redundancy of Radioresistant Signaling Pathways Originating from Insulin-like Growth Factor I Receptor.
D. Yu, H. Watanabe, H. Shibuya, and M. Miura (2003)
J. Biol. Chem. 278, 6702-6709
   Abstract »    Full Text »    PDF »
Cellular stress response and apoptosis in cancer therapy.
I. Herr and K.-M. Debatin (2001)
Blood 98, 2603-2614
   Abstract »    Full Text »    PDF »
Antiapoptotic Activity Is Dispensable for Insulin-like Growth Factor I Receptor-mediated Clonogenic Radioresistance after {gamma}-Irradiation.
M. Tezuka, H. Watanabe, S. Nakamura, D. Yu, W. Aung, T. Sasaki, H. Shibuya, and M. Miura (2001)
Clin. Cancer Res. 7, 3206-3214
   Abstract »    Full Text »    PDF »
A Novel Response of Cancer Cells to Radiation Involves Autophagy and Formation of Acidic Vesicles.
S. Paglin, T. Hollister, T. Delohery, N. Hackett, M. McMahill, E. Sphicas, D. Domingo, and J. Yahalom (2001)
Cancer Res. 61, 439-444
   Abstract »    Full Text »
Phagocytosis of Nonapoptotic Cells Dying by Caspase- Independent Mechanisms.
U. A. Hirt, F. Gantner, and M. Leist (2000)
J. Immunol. 164, 6520-6529
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)